AstraZeneca PLC announced that Enhertu was approved in the EU on April 4, 2025, as the first HER2-directed therapy for patients with HER2-low metastatic breast cancer after at least one endocrine therapy, backed by clinical trial results showing over a year of progression-free survival (13.2 months vs. 8.1 months compared to chemotherapy). AstraZeneca owes $125 million to Daiichi Sankyo due to this milestone.