AstraZeneca announced that Koselugo (selumetinib) received FDA approval on November 20, 2025, for treating adults with neurofibromatosis type 1 and symptomatic, inoperable plexiform neurofibromas, following positive results from the KOMET Phase III trial showing a 20% overall response rate in tumor size reduction. This marks a significant advancement for treatment options in this rare condition.